Drug interactions
Fluticasone inhaled + Nicardipine
Severity: Minor
Fluticasone inhaled and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a modest CYP3A4 inhibitor and may slightly increase systemic fluticasone exposure. Significant corticosteroid effects such as adrenal suppression are mainly reported with strong inhibitors, so the risk is low.
What this interaction means in plain words
Fluticasone inhaled and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine weakly inhibits CYP3A4 metabolism of fluticasone.
What to do
No routine change is needed; watch for signs of systemic corticosteroid excess if high doses are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Fluticasone inhaled with Nicardipine?
MediHelp rates the interaction as minor. Fluticasone inhaled and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a modest CYP3A4 inhibitor and may slightly increase systemic fluticasone exposure. Significant corticosteroid effects such as adrenal suppression are mainly reported with strong inhibitors, so the risk is low.
How serious is the interaction between Fluticasone inhaled and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for signs of systemic corticosteroid excess if high doses are used long term.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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