Drug interactions
Fluticasone inhaled + Quinidine
Severity: Minor
Fluticasone inhaled and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a weak-to-moderate CYP3A4 inhibitor and not a strong one, so its effect on fluticasone is likely small. Systemic exposure to inhaled fluticasone may rise slightly, and corticosteroid adverse effects are possible with long-term use. Clinical significance is probably limited.
What this interaction means in plain words
Fluticasone inhaled and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinidine mildly inhibits CYP3A4, reducing first-pass clearance of swallowed or absorbed fluticasone.
What to do
No routine change is needed. Watch for signs of systemic corticosteroid effect such as cushingoid features or adrenal suppression with prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Quinidine?
MediHelp rates the interaction as minor. Fluticasone inhaled and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine is a weak-to-moderate CYP3A4 inhibitor and not a strong one, so its effect on fluticasone is likely small. Systemic exposure to inhaled fluticasone may rise slightly, and corticosteroid adverse effects are possible with long-term use. Clinical significance is probably limited.
How serious is the interaction between Fluticasone inhaled and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for signs of systemic corticosteroid effect such as cushingoid features or adrenal suppression with prolonged use.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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