Drug interactions
Fluticasone-salmeterol + Givinostat
Severity: Moderate
Fluticasone-salmeterol and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both givinostat and salmeterol can prolong the QT interval, so combined use may increase the risk of serious ventricular arrhythmias such as torsades de pointes. Risk rises with electrolyte disturbance or underlying heart disease.
What this interaction means in plain words
Fluticasone-salmeterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT prolongation.
What to do
Perform ECGs at initiation and during co-use and keep potassium and magnesium normal. Withhold givinostat if QTc becomes markedly prolonged as per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Givinostat?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both givinostat and salmeterol can prolong the QT interval, so combined use may increase the risk of serious ventricular arrhythmias such as torsades de pointes. Risk rises with electrolyte disturbance or underlying heart disease.
How serious is the interaction between Fluticasone-salmeterol and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECGs at initiation and during co-use and keep potassium and magnesium normal. Withhold givinostat if QTc becomes markedly prolonged as per labeling.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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