Drug interactions
Fluticasone-salmeterol + Ivosidenib
Severity: Moderate
Fluticasone-salmeterol and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer in vitro and clinically, so it may lower rather than raise salmeterol and fluticasone concentrations, potentially reducing efficacy. It also prolongs the QT interval, which may add to salmeterol cardiac effects.
What this interaction means in plain words
Fluticasone-salmeterol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Ivosidenib belongs to Oncology.
Why it happens
CYP3A4 induction may reduce salmeterol and fluticasone exposure, and both ivosidenib and salmeterol can prolong the QT interval.
What to do
Monitor asthma or COPD control and ECG during coadministration. Correct potassium and magnesium and adjust therapy if control worsens or QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Ivosidenib?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer in vitro and clinically, so it may lower rather than raise salmeterol and fluticasone concentrations, potentially reducing efficacy. It also prolongs the QT interval, which may add to salmeterol cardiac effects.
How serious is the interaction between Fluticasone-salmeterol and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and ECG during coadministration. Correct potassium and magnesium and adjust therapy if control worsens or QTc lengthens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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