Drug interactions
Fluticasone-salmeterol + Larotrectinib
Severity: Minor
Fluticasone-salmeterol and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it may slightly raise fluticasone exposure. The effect with inhaled doses is probably negligible in practice.
What this interaction means in plain words
Fluticasone-salmeterol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reduces fluticasone metabolism; the mechanism is not firmly established.
What to do
No specific action is needed beyond awareness. Monitor for signs of corticosteroid excess in long-term concurrent use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Fluticasone-salmeterol with Larotrectinib?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak CYP3A4 inhibitor in vitro, so it may slightly raise fluticasone exposure. The effect with inhaled doses is probably negligible in practice.
How serious is the interaction between Fluticasone-salmeterol and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond awareness. Monitor for signs of corticosteroid excess in long-term concurrent use.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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