Drug interactions
Fluticasone-salmeterol + Rifabutin
Severity: Minor
Fluticasone-salmeterol and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower fluticasone and salmeterol concentrations. Since inhaled doses act largely locally, the clinical effect is probably small, but asthma or COPD control could be reduced.
What this interaction means in plain words
Fluticasone-salmeterol and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, increasing metabolism of fluticasone and salmeterol.
What to do
Monitor respiratory symptoms and exacerbation frequency after starting rifabutin and increase inhaler therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Rifabutin?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces CYP3A4 and may lower fluticasone and salmeterol concentrations. Since inhaled doses act largely locally, the clinical effect is probably small, but asthma or COPD control could be reduced.
How serious is the interaction between Fluticasone-salmeterol and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and exacerbation frequency after starting rifabutin and increase inhaler therapy only if control worsens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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