Drug interactions
Fluticasone-salmeterol + Spironolactone
Severity: Minor
Fluticasone-salmeterol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone raises serum potassium by blocking aldosterone, while salmeterol can lower it. The net effect is unpredictable and usually minor, and salmeterol may partly offset spironolactone-related hyperkalemia.
What this interaction means in plain words
Fluticasone-salmeterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing potassium effects: aldosterone antagonism versus beta2-mediated intracellular shift.
What to do
No routine adjustment is needed; monitor potassium periodically, especially in renal impairment or heart failure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Spironolactone?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone raises serum potassium by blocking aldosterone, while salmeterol can lower it. The net effect is unpredictable and usually minor, and salmeterol may partly offset spironolactone-related hyperkalemia.
How serious is the interaction between Fluticasone-salmeterol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor potassium periodically, especially in renal impairment or heart failure.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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