Drug interactions
Fluticasone-vilanterol + Formoterol
Severity: Major
Fluticasone-vilanterol and Formoterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and vilanterol are both long-acting beta2-agonists, so using them together duplicates therapy and increases tachycardia, tremor, hypokalemia and QT prolongation. This offers no added benefit and raises the risk of adverse cardiovascular events.
What this interaction means in plain words
Fluticasone-vilanterol and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Formoterol belongs to Respiratory.
Why it happens
Duplicate beta2-adrenergic agonism producing additive cardiovascular and metabolic effects.
What to do
Avoid concurrent use of two long-acting beta-agonists; use only one LABA and keep short-acting agents for rescue.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-vilanterol
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Formoterol?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol and vilanterol are both long-acting beta2-agonists, so using them together duplicates therapy and increases tachycardia, tremor, hypokalemia and QT prolongation. This offers no added benefit and raises the risk of adverse cardiovascular events.
How serious is the interaction between Fluticasone-vilanterol and Formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists; use only one LABA and keep short-acting agents for rescue.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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