Drug interactions
Fluticasone-vilanterol + Fosphenytoin
Severity: Minor
Fluticasone-vilanterol and Fosphenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which may lower exposure to fluticasone furoate and vilanterol. This could reduce control of airway disease, though the clinical effect is usually limited because of inhaled delivery.
What this interaction means in plain words
Fluticasone-vilanterol and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Fosphenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases the metabolism of vilanterol and fluticasone furoate.
What to do
Monitor respiratory symptoms and exacerbation frequency. Consider adjusting asthma or COPD therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Fosphenytoin?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Fosphenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosphenytoin is converted to phenytoin, a CYP3A4 inducer, which may lower exposure to fluticasone furoate and vilanterol. This could reduce control of airway disease, though the clinical effect is usually limited because of inhaled delivery.
How serious is the interaction between Fluticasone-vilanterol and Fosphenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and exacerbation frequency. Consider adjusting asthma or COPD therapy if control worsens.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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