Drug interactions
Fluticasone-vilanterol + Indapamide
Severity: Moderate
Fluticasone-vilanterol and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and has been linked to QT prolongation. Vilanterol also lowers potassium, so the combination raises the risk of arrhythmia.
What this interaction means in plain words
Fluticasone-vilanterol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Indapamide belongs to Cardiovascular.
Why it happens
Additive hypokalemia and QTc prolongation from diuretic potassium loss and beta2-agonist intracellular potassium shift.
What to do
Monitor serum potassium and magnesium and replace as needed. Obtain ECG if the patient has other arrhythmia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Indapamide
Frequently asked questions
Can I take Fluticasone-vilanterol with Indapamide?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can cause hypokalemia and has been linked to QT prolongation. Vilanterol also lowers potassium, so the combination raises the risk of arrhythmia.
How serious is the interaction between Fluticasone-vilanterol and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace as needed. Obtain ECG if the patient has other arrhythmia risks.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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