Drug interactions
Fluticasone-vilanterol + Indinavir
Severity: Moderate
Fluticasone-vilanterol and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 inhibitor and can increase exposure to fluticasone furoate and vilanterol. This may lead to systemic corticosteroid effects and increased beta-agonist cardiovascular effects.
What this interaction means in plain words
Fluticasone-vilanterol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for adrenal suppression, tachycardia and hypokalemia. Consider an alternative inhaled corticosteroid for long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Indinavir?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a CYP3A4 inhibitor and can increase exposure to fluticasone furoate and vilanterol. This may lead to systemic corticosteroid effects and increased beta-agonist cardiovascular effects.
How serious is the interaction between Fluticasone-vilanterol and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adrenal suppression, tachycardia and hypokalemia. Consider an alternative inhaled corticosteroid for long-term use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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