Drug interactions
Fluticasone-vilanterol + Isoniazid
Severity: Minor
Fluticasone-vilanterol and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak CYP3A4 inhibitor, and fluticasone furoate and vilanterol are CYP3A4 substrates. Any rise in exposure to the inhaled drugs is expected to be small and unlikely to matter clinically.
What this interaction means in plain words
Fluticasone-vilanterol and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4 may slightly reduce metabolism of fluticasone furoate and vilanterol.
What to do
No dose change is needed; be aware of possible systemic corticosteroid or beta-agonist effects with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Isoniazid
Frequently asked questions
Can I take Fluticasone-vilanterol with Isoniazid?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid is a weak CYP3A4 inhibitor, and fluticasone furoate and vilanterol are CYP3A4 substrates. Any rise in exposure to the inhaled drugs is expected to be small and unlikely to matter clinically.
How serious is the interaction between Fluticasone-vilanterol and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; be aware of possible systemic corticosteroid or beta-agonist effects with long-term use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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