Drug interactions
Fluticasone-vilanterol + Methyclothiazide
Severity: Moderate
Fluticasone-vilanterol and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both vilanterol and thiazide diuretics can lower serum potassium. Together they may cause clinically significant hypokalemia and ECG changes, particularly in patients with cardiac disease.
What this interaction means in plain words
Fluticasone-vilanterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 agonist intracellular potassium shift and thiazide renal potassium loss.
What to do
Monitor serum potassium periodically and replace as needed, especially when starting or increasing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Methyclothiazide?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both vilanterol and thiazide diuretics can lower serum potassium. Together they may cause clinically significant hypokalemia and ECG changes, particularly in patients with cardiac disease.
How serious is the interaction between Fluticasone-vilanterol and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace as needed, especially when starting or increasing doses.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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