Drug interactions
Fluticasone-vilanterol + Olodaterol inhaled
Severity: Major
Fluticasone-vilanterol and Olodaterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol and olodaterol are both long-acting beta2-agonists, so combining them duplicates therapy. This increases the risk of tachycardia, palpitations, tremor and hypokalemia without added benefit.
What this interaction means in plain words
Fluticasone-vilanterol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta2-adrenergic receptor agonism from two drugs of the same class.
What to do
Avoid using two LABAs together and keep one in the regimen. If both have been used, stop one and monitor heart rate, blood pressure and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Olodaterol inhaled?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilanterol and olodaterol are both long-acting beta2-agonists, so combining them duplicates therapy. This increases the risk of tachycardia, palpitations, tremor and hypokalemia without added benefit.
How serious is the interaction between Fluticasone-vilanterol and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two LABAs together and keep one in the regimen. If both have been used, stop one and monitor heart rate, blood pressure and potassium.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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