Drug interactions
Fluticasone-vilanterol + Penbutolol
Severity: Major
Fluticasone-vilanterol and Penbutolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a non-selective beta-blocker that opposes the bronchodilating action of vilanterol. It can cause bronchospasm and reduced bronchodilator response, especially in patients with COPD or asthma.
What this interaction means in plain words
Fluticasone-vilanterol and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors in the airways.
What to do
Avoid non-selective beta-blockers in patients using beta-agonist bronchodilators. If a beta-blocker is needed, choose a cardioselective beta-1 agent at the lowest effective dose and monitor respiratory status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Penbutolol?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a non-selective beta-blocker that opposes the bronchodilating action of vilanterol. It can cause bronchospasm and reduced bronchodilator response, especially in patients with COPD or asthma.
How serious is the interaction between Fluticasone-vilanterol and Penbutolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients using beta-agonist bronchodilators. If a beta-blocker is needed, choose a cardioselective beta-1 agent at the lowest effective dose and monitor respiratory status.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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