Drug interactions
Fluticasone-vilanterol + Phenobarbital
Severity: Minor
Fluticasone-vilanterol and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a CYP3A4 inducer and may reduce systemic exposure to fluticasone furoate and vilanterol. The effect on inhaled therapy is likely small because much of the benefit is local, but respiratory control could be reduced.
What this interaction means in plain words
Fluticasone-vilanterol and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increasing metabolism of fluticasone furoate and vilanterol.
What to do
Monitor asthma or COPD control and adjust therapy if symptoms worsen. No empiric dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Phenobarbital?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital is a CYP3A4 inducer and may reduce systemic exposure to fluticasone furoate and vilanterol. The effect on inhaled therapy is likely small because much of the benefit is local, but respiratory control could be reduced.
How serious is the interaction between Fluticasone-vilanterol and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and adjust therapy if symptoms worsen. No empiric dose change is needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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