Drug interactions
Fluticasone-vilanterol + Phenytoin
Severity: Minor
Fluticasone-vilanterol and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower exposure to fluticasone furoate and vilanterol. This could reduce asthma or COPD control, though the clinical effect of inhaled doses is uncertain.
What this interaction means in plain words
Fluticasone-vilanterol and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Phenytoin belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases metabolism of fluticasone furoate and vilanterol.
What to do
Monitor respiratory control and consider adjusting therapy if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Phenytoin?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP3A4 and may lower exposure to fluticasone furoate and vilanterol. This could reduce asthma or COPD control, though the clinical effect of inhaled doses is uncertain.
How serious is the interaction between Fluticasone-vilanterol and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory control and consider adjusting therapy if symptoms worsen.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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