Drug interactions
Fluticasone-vilanterol + Protriptyline
Severity: Major
Fluticasone-vilanterol and Protriptyline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia, hypertension and arrhythmias. Protriptyline also prolongs the QTc interval, adding to arrhythmia risk with vilanterol.
What this interaction means in plain words
Fluticasone-vilanterol and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive adrenergic and QT-prolonging effects; TCAs inhibit catecholamine reuptake and potentiate beta-agonist cardiovascular actions.
What to do
Avoid the combination where possible, or monitor heart rate, blood pressure and ECG closely. Correct electrolyte abnormalities and consider a different bronchodilator or antidepressant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Protriptyline?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia, hypertension and arrhythmias. Protriptyline also prolongs the QTc interval, adding to arrhythmia risk with vilanterol.
How serious is the interaction between Fluticasone-vilanterol and Protriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor heart rate, blood pressure and ECG closely. Correct electrolyte abnormalities and consider a different bronchodilator or antidepressant.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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