Drug interactions
Fluticasone-vilanterol + Saquinavir
Severity: Major
Fluticasone-vilanterol and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir boosted with ritonavir prolongs the QT and PR intervals. It is also a strong CYP3A4 inhibitor that can raise vilanterol and fluticasone furoate exposure, increasing cardiovascular and systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-vilanterol and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition reducing vilanterol and fluticasone clearance.
What to do
Avoid the combination if possible, or obtain a baseline ECG and monitor QTc, heart rate and potassium. Watch for systemic corticosteroid effects with prolonged use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Saquinavir?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir boosted with ritonavir prolongs the QT and PR intervals. It is also a strong CYP3A4 inhibitor that can raise vilanterol and fluticasone furoate exposure, increasing cardiovascular and systemic corticosteroid effects.
How serious is the interaction between Fluticasone-vilanterol and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or obtain a baseline ECG and monitor QTc, heart rate and potassium. Watch for systemic corticosteroid effects with prolonged use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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