Drug interactions
Fluticasone-vilanterol + Thiothixene
Severity: Moderate
Fluticasone-vilanterol and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene, an antipsychotic, can prolong the QTc interval. Combined with vilanterol, which may cause tachycardia and lower potassium, the risk of ventricular arrhythmia may rise.
What this interaction means in plain words
Fluticasone-vilanterol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG in patients with cardiac disease or other QT risk factors, and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fluticasone-vilanterol with Thiothixene?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene, an antipsychotic, can prolong the QTc interval. Combined with vilanterol, which may cause tachycardia and lower potassium, the risk of ventricular arrhythmia may rise.
How serious is the interaction between Fluticasone-vilanterol and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac disease or other QT risk factors, and correct electrolyte disturbances.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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