Drug interactions
Fluvastatin + Glyburide-metformin
Severity: Minor
Fluvastatin and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin inhibits CYP2C9, which contributes to glyburide metabolism, and may modestly increase glyburide levels. The clinical effect is usually small, but hypoglycemia is possible.
What this interaction means in plain words
Fluvastatin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated glyburide metabolism by fluvastatin.
What to do
Monitor blood glucose when starting or stopping fluvastatin and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Glyburide-metformin?
MediHelp rates the interaction as minor. Fluvastatin and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin inhibits CYP2C9, which contributes to glyburide metabolism, and may modestly increase glyburide levels. The clinical effect is usually small, but hypoglycemia is possible.
How serious is the interaction between Fluvastatin and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluvastatin and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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