Drug interactions
Fluvastatin + Ivosidenib
Severity: Moderate
Fluvastatin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9, the main enzyme metabolising fluvastatin. Fluvastatin exposure may fall, reducing its lipid-lowering effect.
What this interaction means in plain words
Fluvastatin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9, accelerating fluvastatin metabolism.
What to do
Monitor the lipid profile after starting ivosidenib and increase the fluvastatin dose or switch to a statin not dependent on CYP2C9 if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Fluvastatin with Ivosidenib?
MediHelp rates the interaction as moderate. Fluvastatin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9, the main enzyme metabolising fluvastatin. Fluvastatin exposure may fall, reducing its lipid-lowering effect.
How serious is the interaction between Fluvastatin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile after starting ivosidenib and increase the fluvastatin dose or switch to a statin not dependent on CYP2C9 if control is lost.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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