Drug interactions
Fluvastatin + Metformin-pioglitazone
Severity: Minor
Fluvastatin and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone has been proposed to inhibit OATP1B1 weakly, and fluvastatin is mainly cleared by CYP2C9. A meaningful rise in fluvastatin exposure or myopathy has not been well established. The interaction is mostly theoretical.
What this interaction means in plain words
Fluvastatin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Theoretical OATP1B1 inhibition by pioglitazone could increase statin exposure; not well established.
What to do
No dose change is usually needed; advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Fluvastatin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone has been proposed to inhibit OATP1B1 weakly, and fluvastatin is mainly cleared by CYP2C9. A meaningful rise in fluvastatin exposure or myopathy has not been well established. The interaction is mostly theoretical.
How serious is the interaction between Fluvastatin and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise patients to report unexplained muscle pain or weakness and check CK if symptoms occur.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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