Drug interactions
Fluvastatin + Metformin-repaglinide
Severity: Minor
Fluvastatin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 substrate and weak inhibitor, so it could modestly raise statin levels. Fluvastatin is mainly cleared by CYP2C9 and is much less dependent on OATP1B1 than other statins, so clinically relevant myopathy is unlikely.
What this interaction means in plain words
Fluvastatin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible weak inhibition of OATP1B1-mediated hepatic statin uptake.
What to do
No dose change is generally required; advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Fluvastatin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is an OATP1B1 substrate and weak inhibitor, so it could modestly raise statin levels. Fluvastatin is mainly cleared by CYP2C9 and is much less dependent on OATP1B1 than other statins, so clinically relevant myopathy is unlikely.
How serious is the interaction between Fluvastatin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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