Drug interactions
Fluvastatin + Nelfinavir
Severity: Moderate
Fluvastatin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may modestly raise fluvastatin exposure through hepatic uptake transporter inhibition, which could increase the risk of muscle toxicity. Fluvastatin is not primarily CYP3A4 metabolized, so the effect is expected to be smaller than with other statins.
What this interaction means in plain words
Fluvastatin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of fluvastatin by nelfinavir.
What to do
Use the lowest effective fluvastatin dose and counsel patients to report unexplained muscle pain or weakness. Check creatine kinase if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvastatin and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluvastatin with Nelfinavir?
MediHelp rates the interaction as moderate. Fluvastatin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may modestly raise fluvastatin exposure through hepatic uptake transporter inhibition, which could increase the risk of muscle toxicity. Fluvastatin is not primarily CYP3A4 metabolized, so the effect is expected to be smaller than with other statins.
How serious is the interaction between Fluvastatin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and counsel patients to report unexplained muscle pain or weakness. Check creatine kinase if symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
