Drug interactions
Fluvastatin + Niacin
Severity: Moderate
Fluvastatin and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lipid-modifying doses of niacin given with a statin may add to the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at high niacin doses and in patients with renal impairment or advanced age.
What this interaction means in plain words
Fluvastatin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Niacin belongs to Cardiovascular.
Why it happens
Additive myotoxicity; niacin may also contribute to muscle injury through an unclear mechanism.
What to do
Use the lowest effective doses and educate the patient to report muscle pain, weakness or dark urine. Check CK and renal function if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Fluvastatin with Niacin?
MediHelp rates the interaction as moderate. Fluvastatin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lipid-modifying doses of niacin given with a statin may add to the risk of myopathy and rarely rhabdomyolysis. The risk appears greatest at high niacin doses and in patients with renal impairment or advanced age.
How serious is the interaction between Fluvastatin and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and educate the patient to report muscle pain, weakness or dark urine. Check CK and renal function if symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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