Drug interactions
Fluvastatin + Pazopanib
Severity: Moderate
Fluvastatin and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 and some CYP enzymes in vitro, and could raise fluvastatin exposure. This may increase the chance of myopathy, and pazopanib is also hepatotoxic.
What this interaction means in plain words
Fluvastatin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Pazopanib inhibits OATP1B1 and CYP2C9 in vitro, which may reduce fluvastatin clearance.
What to do
Monitor liver enzymes and muscle symptoms. Check creatine kinase if pain or weakness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Fluvastatin with Pazopanib?
MediHelp rates the interaction as moderate. Fluvastatin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1 and some CYP enzymes in vitro, and could raise fluvastatin exposure. This may increase the chance of myopathy, and pazopanib is also hepatotoxic.
How serious is the interaction between Fluvastatin and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and muscle symptoms. Check creatine kinase if pain or weakness occurs.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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