Drug interactions
Fluvastatin + Primidone
Severity: Minor
Fluvastatin and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised partly to phenobarbital and induces hepatic enzymes, which may reduce fluvastatin levels and weaken its cholesterol-lowering effect.
What this interaction means in plain words
Fluvastatin and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction increases CYP2C9-mediated fluvastatin clearance.
What to do
Recheck the lipid profile after changes in primidone therapy and titrate fluvastatin accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Fluvastatin with Primidone?
MediHelp rates the interaction as minor. Fluvastatin and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolised partly to phenobarbital and induces hepatic enzymes, which may reduce fluvastatin levels and weaken its cholesterol-lowering effect.
How serious is the interaction between Fluvastatin and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recheck the lipid profile after changes in primidone therapy and titrate fluvastatin accordingly.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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