Drug interactions
Fluvastatin + Sacubitril-valsartan
Severity: Minor
Fluvastatin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril inhibits OATP1B1 and OATP1B3 in vitro, and sacubitril-valsartan has been shown to raise exposure to some statins, notably atorvastatin. Fluvastatin is mainly metabolised by CYP2C9 but is also an OATP substrate, so a modest increase in exposure is possible, with a small added risk of myopathy.
What this interaction means in plain words
Fluvastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of the statin by sacubitril.
What to do
No empirical dose change is required. Advise patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Fluvastatin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril inhibits OATP1B1 and OATP1B3 in vitro, and sacubitril-valsartan has been shown to raise exposure to some statins, notably atorvastatin. Fluvastatin is mainly metabolised by CYP2C9 but is also an OATP substrate, so a modest increase in exposure is possible, with a small added risk of myopathy.
How serious is the interaction between Fluvastatin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Advise patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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