Drug interactions
Folic acid + Hydrochlorothiazide-olmesartan
Severity: Minor
Folic acid and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly increase urinary folate loss, but clinically significant folate deficiency from this is not well established.
What this interaction means in plain words
Folic acid and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Possible increased renal excretion of folate; mechanism is not well established.
What to do
No action needed in most patients; consider folate status if deficiency risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Folic acid and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly increase urinary folate loss, but clinically significant folate deficiency from this is not well established.
How serious is the interaction between Folic acid and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed in most patients; consider folate status if deficiency risk factors are present.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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