Drug interactions
Formoterol + Fosinopril-hydrochlorothiazide
Severity: Moderate
Formoterol and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium through beta-2 stimulation, and hydrochlorothiazide adds renal potassium loss. Hypokalemia may increase the risk of arrhythmias, especially at high formoterol doses or in hypoxic patients.
What this interaction means in plain words
Formoterol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from beta-2 mediated potassium shift and thiazide kaliuresis.
What to do
Monitor serum potassium in patients on high-dose formoterol or with other risk factors, and supplement as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Formoterol and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium through beta-2 stimulation, and hydrochlorothiazide adds renal potassium loss. Hypokalemia may increase the risk of arrhythmias, especially at high formoterol doses or in hypoxic patients.
How serious is the interaction between Formoterol and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on high-dose formoterol or with other risk factors, and supplement as required.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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