Drug interactions
Formoterol + Histrelin
Severity: Moderate
Formoterol and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and formoterol may add to this effect. The combination may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Formoterol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation; androgen deprivation lengthens repolarization while beta-agonists can cause hypokalemia and QT effects.
What to do
Consider baseline and periodic ECG and electrolyte monitoring in patients with cardiac risk factors. Correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Formoterol with Histrelin?
MediHelp rates the interaction as moderate. Formoterol and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and formoterol may add to this effect. The combination may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Formoterol and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECG and electrolyte monitoring in patients with cardiac risk factors. Correct potassium and magnesium deficits.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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