Drug interactions
Formoterol + Quizartinib
Severity: Major
Formoterol and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib markedly prolongs the QT interval, and formoterol can also affect repolarization and lower potassium. Together they may increase the risk of torsades de pointes, especially when electrolytes are abnormal.
What this interaction means in plain words
Formoterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol belongs to Respiratory; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation, with formoterol-induced hypokalemia adding to the arrhythmic risk.
What to do
Monitor ECG more often and keep potassium and magnesium within normal range. Consider an alternative bronchodilator or reduce the quizartinib dose according to labeling if QTc lengthens significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Formoterol with Quizartinib?
MediHelp rates the interaction as major. Formoterol and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib markedly prolongs the QT interval, and formoterol can also affect repolarization and lower potassium. Together they may increase the risk of torsades de pointes, especially when electrolytes are abnormal.
How serious is the interaction between Formoterol and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more often and keep potassium and magnesium within normal range. Consider an alternative bronchodilator or reduce the quizartinib dose according to labeling if QTc lengthens significantly.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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