Drug interactions
Formoterol-mometasone + Methyclothiazide
Severity: Moderate
Formoterol-mometasone and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both a beta-2 agonist and a thiazide diuretic can lower serum potassium. Together they may cause clinically relevant hypokalemia, which raises the risk of arrhythmias, particularly in patients with cardiac disease or taking high doses of formoterol.
What this interaction means in plain words
Formoterol-mometasone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta-2 mediated intracellular potassium shift (formoterol) and renal potassium loss (thiazide).
What to do
Check serum potassium and magnesium at baseline and periodically, especially in patients with heart disease or high-dose beta-agonist use. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Methyclothiazide?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both a beta-2 agonist and a thiazide diuretic can lower serum potassium. Together they may cause clinically relevant hypokalemia, which raises the risk of arrhythmias, particularly in patients with cardiac disease or taking high doses of formoterol.
How serious is the interaction between Formoterol-mometasone and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, especially in patients with heart disease or high-dose beta-agonist use. Replace potassium as needed.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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