Drug interactions
Formoterol-mometasone + Nefazodone
Severity: Moderate
Formoterol-mometasone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4, which metabolizes mometasone. Systemic exposure to inhaled mometasone may increase, raising the risk of systemic corticosteroid effects such as adrenal suppression and Cushing syndrome with prolonged use.
What this interaction means in plain words
Formoterol-mometasone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by nefazodone reduces mometasone clearance.
What to do
Monitor for signs of corticosteroid excess during long-term co-therapy and consider an alternative antidepressant or a corticosteroid less dependent on CYP3A4, such as beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Formoterol-mometasone and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Nefazodone?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone strongly inhibits CYP3A4, which metabolizes mometasone. Systemic exposure to inhaled mometasone may increase, raising the risk of systemic corticosteroid effects such as adrenal suppression and Cushing syndrome with prolonged use.
How serious is the interaction between Formoterol-mometasone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during long-term co-therapy and consider an alternative antidepressant or a corticosteroid less dependent on CYP3A4, such as beclomethasone.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
