Drug interactions
Formoterol-mometasone + Penbutolol
Severity: Major
Formoterol-mometasone and Penbutolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a non-selective beta-blocker that antagonizes the bronchodilator effect of formoterol and may provoke bronchospasm in asthma or COPD. The result can be reduced asthma control and diminished rescue response.
What this interaction means in plain words
Formoterol-mometasone and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive beta-adrenoceptor blockade opposes beta-2 agonist bronchodilation.
What to do
Avoid non-selective beta-blockers in patients with asthma; if a beta-blocker is required in COPD, choose a cardioselective agent and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Penbutolol?
MediHelp rates the interaction as major. Formoterol-mometasone and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a non-selective beta-blocker that antagonizes the bronchodilator effect of formoterol and may provoke bronchospasm in asthma or COPD. The result can be reduced asthma control and diminished rescue response.
How serious is the interaction between Formoterol-mometasone and Penbutolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with asthma; if a beta-blocker is required in COPD, choose a cardioselective agent and monitor respiratory function.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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