Drug interactions
Formoterol-mometasone + Phenoxybenzamine
Severity: Moderate
Formoterol-mometasone and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an irreversible alpha-blocker causing vasodilation and reflex tachycardia. Formoterol's beta-2 vasodilation may add to hypotension and tachycardia.
What this interaction means in plain words
Formoterol-mometasone and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from alpha-blockade and beta-2 agonism, with reflex tachycardia.
What to do
Monitor blood pressure and heart rate, particularly during initiation or dose increases, and counsel on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is an irreversible alpha-blocker causing vasodilation and reflex tachycardia. Formoterol's beta-2 vasodilation may add to hypotension and tachycardia.
How serious is the interaction between Formoterol-mometasone and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly during initiation or dose increases, and counsel on orthostatic symptoms.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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