Drug interactions
Formoterol-mometasone + Phenylephrine
Severity: Moderate
Formoterol-mometasone and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity, so systemic phenylephrine, such as in oral decongestants, may add to the heart rate and blood pressure effects of formoterol. This matters most in patients with hypertension, arrhythmia or coronary disease.
What this interaction means in plain words
Formoterol-mometasone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Phenylephrine belongs to Respiratory.
Why it happens
Additive adrenergic stimulation through beta-2 agonism (formoterol) and alpha-1 agonism (phenylephrine).
What to do
Monitor blood pressure and heart rate and avoid systemic decongestants in patients with cardiovascular disease. Advise patients to report palpitations or chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Formoterol-mometasone with Phenylephrine?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity, so systemic phenylephrine, such as in oral decongestants, may add to the heart rate and blood pressure effects of formoterol. This matters most in patients with hypertension, arrhythmia or coronary disease.
How serious is the interaction between Formoterol-mometasone and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid systemic decongestants in patients with cardiovascular disease. Advise patients to report palpitations or chest pain.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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