Drug interactions
Formoterol-mometasone + Pimozide
Severity: Major
Formoterol-mometasone and Pimozide: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide markedly prolongs the QT interval and formoterol can add to repolarization effects and lower potassium. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Formoterol-mometasone and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Pimozide belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, with beta-2-agonist-induced hypokalemia increasing proarrhythmic risk.
What to do
Avoid the combination if possible, or obtain a baseline ECG and keep potassium and magnesium normal with periodic ECG follow-up. Consider an alternative bronchodilator regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Pimozide?
MediHelp rates the interaction as major. Formoterol-mometasone and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimozide markedly prolongs the QT interval and formoterol can add to repolarization effects and lower potassium. The combination raises the risk of torsades de pointes.
How serious is the interaction between Formoterol-mometasone and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or obtain a baseline ECG and keep potassium and magnesium normal with periodic ECG follow-up. Consider an alternative bronchodilator regimen.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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