Drug interactions
Formoterol-mometasone + Protriptyline
Severity: Major
Formoterol-mometasone and Protriptyline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as protriptyline can enhance the cardiovascular effects of beta-2 agonists. Formoterol can prolong the QT interval and increase heart rate, and protriptyline has similar effects, so the risk of arrhythmia is raised.
What this interaction means in plain words
Formoterol-mometasone and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects, with tricyclic inhibition of catecholamine reuptake.
What to do
Monitor ECG and heart rate, and check potassium. Consider a non-tricyclic antidepressant if the patient has cardiac risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Protriptyline?
MediHelp rates the interaction as major. Formoterol-mometasone and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants such as protriptyline can enhance the cardiovascular effects of beta-2 agonists. Formoterol can prolong the QT interval and increase heart rate, and protriptyline has similar effects, so the risk of arrhythmia is raised.
How serious is the interaction between Formoterol-mometasone and Protriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and check potassium. Consider a non-tricyclic antidepressant if the patient has cardiac risk factors.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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