Drug interactions
Formoterol-mometasone + Saquinavir
Severity: Major
Formoterol-mometasone and Saquinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually given with ritonavir, inhibits CYP3A4 and can increase systemic exposure to inhaled mometasone. This raises the risk of systemic corticosteroid effects such as adrenal suppression and Cushing's syndrome.
What this interaction means in plain words
Formoterol-mometasone and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition reduces mometasone clearance.
What to do
Prefer an inhaled steroid less dependent on CYP3A4, such as beclomethasone. If the combination is continued, monitor for Cushingoid signs and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Formoterol-mometasone
Frequently asked questions
Can I take Formoterol-mometasone with Saquinavir?
MediHelp rates the interaction as major. Formoterol-mometasone and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir, usually given with ritonavir, inhibits CYP3A4 and can increase systemic exposure to inhaled mometasone. This raises the risk of systemic corticosteroid effects such as adrenal suppression and Cushing's syndrome.
How serious is the interaction between Formoterol-mometasone and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an inhaled steroid less dependent on CYP3A4, such as beclomethasone. If the combination is continued, monitor for Cushingoid signs and adrenal suppression.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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