Drug interactions
Forskolin + Tolbutamide
Severity: Minor
Forskolin and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Forskolin activates adenylyl cyclase and may influence insulin release and glucose handling. It could theoretically add to the hypoglycemic effect of tolbutamide, but clinical data are lacking.
What this interaction means in plain words
Forskolin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Forskolin raises intracellular cAMP, which may enhance insulin secretion in an additive fashion with sulfonylureas.
What to do
Monitor blood glucose if forskolin supplements are used with tolbutamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Forskolin with Tolbutamide?
MediHelp rates the interaction as minor. Forskolin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Forskolin activates adenylyl cyclase and may influence insulin release and glucose handling. It could theoretically add to the hypoglycemic effect of tolbutamide, but clinical data are lacking.
How serious is the interaction between Forskolin and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if forskolin supplements are used with tolbutamide.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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