Drug interactions
Fosamprenavir + Imatinib
Severity: Moderate
Fosamprenavir and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which may raise imatinib concentrations. This may increase imatinib adverse effects.
What this interaction means in plain words
Fosamprenavir and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4-mediated imatinib metabolism.
What to do
Monitor for imatinib toxicity, blood counts and liver function. Reduce the imatinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fosamprenavir with Imatinib?
MediHelp rates the interaction as moderate. Fosamprenavir and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, which may raise imatinib concentrations. This may increase imatinib adverse effects.
How serious is the interaction between Fosamprenavir and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity, blood counts and liver function. Reduce the imatinib dose if adverse effects occur.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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