Drug interactions
Fosamprenavir + Maprotiline
Severity: Major
Fosamprenavir and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, via its active metabolite amprenavir, may raise maprotiline concentrations, increasing the risk of anticholinergic effects, sedation, seizures and cardiac toxicity. Ritonavir-boosted regimens would have a greater effect.
What this interaction means in plain words
Fosamprenavir and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 and CYP2D6-mediated metabolism of maprotiline (especially when boosted with ritonavir).
What to do
Consider an alternative antidepressant. If combined, start maprotiline at a low dose, monitor for toxicity and ECG changes, and consider checking drug levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Maprotiline?
MediHelp rates the interaction as major. Fosamprenavir and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, via its active metabolite amprenavir, may raise maprotiline concentrations, increasing the risk of anticholinergic effects, sedation, seizures and cardiac toxicity. Ritonavir-boosted regimens would have a greater effect.
How serious is the interaction between Fosamprenavir and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidepressant. If combined, start maprotiline at a low dose, monitor for toxicity and ECG changes, and consider checking drug levels.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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