Drug interactions
Fosamprenavir + Midazolam
Severity: Contraindicated
Fosamprenavir and Midazolam: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active form amprenavir inhibits CYP3A4, increases midazolam levels, which may lead to prolonged sedation and respiratory depression.
What this interaction means in plain words
Fosamprenavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amprenavir inhibits CYP3A4, reducing midazolam metabolism.
What to do
Avoid oral midazolam. Use reduced-dose single parenteral midazolam in a monitored setting if essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
- Itraconazole + Midazolam Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Midazolam?
MediHelp rates the interaction as contraindicated. Fosamprenavir and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir, whose active form amprenavir inhibits CYP3A4, increases midazolam levels, which may lead to prolonged sedation and respiratory depression.
How serious is the interaction between Fosamprenavir and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. Use reduced-dose single parenteral midazolam in a monitored setting if essential.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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