Drug interactions
Fosamprenavir + Nicardipine
Severity: Moderate
Fosamprenavir and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4, and with ritonavir the inhibition is strong. Nicardipine exposure may rise, causing hypotension, tachycardia and edema.
What this interaction means in plain words
Fosamprenavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir, particularly with ritonavir, inhibits CYP3A4 and reduces nicardipine clearance.
What to do
Start nicardipine at a low dose and titrate to blood pressure and heart rate; reduce the dose if adverse vasodilatory effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Fosamprenavir with Nicardipine?
MediHelp rates the interaction as moderate. Fosamprenavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4, and with ritonavir the inhibition is strong. Nicardipine exposure may rise, causing hypotension, tachycardia and edema.
How serious is the interaction between Fosamprenavir and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nicardipine at a low dose and titrate to blood pressure and heart rate; reduce the dose if adverse vasodilatory effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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