Drug interactions
Fosamprenavir + Paclitaxel
Severity: Moderate
Fosamprenavir and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, which inhibits CYP3A4 and can raise paclitaxel concentrations. Increased exposure could worsen neutropenia and peripheral neuropathy, though the size of the effect is not well defined.
What this interaction means in plain words
Fosamprenavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibits CYP3A4-mediated paclitaxel metabolism, increasing paclitaxel exposure.
What to do
Monitor blood counts and neuropathy closely and reduce paclitaxel dose if toxicity develops; consider a non-boosted or alternative antiretroviral if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Fosamprenavir with Paclitaxel?
MediHelp rates the interaction as moderate. Fosamprenavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, which inhibits CYP3A4 and can raise paclitaxel concentrations. Increased exposure could worsen neutropenia and peripheral neuropathy, though the size of the effect is not well defined.
How serious is the interaction between Fosamprenavir and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely and reduce paclitaxel dose if toxicity develops; consider a non-boosted or alternative antiretroviral if feasible.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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