Drug interactions
Fosamprenavir + Prednisone
Severity: Moderate
Fosamprenavir and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and may modestly increase prednisolone exposure, raising the risk of corticosteroid adverse effects with prolonged use. Corticosteroids may in turn lower amprenavir levels slightly.
What this interaction means in plain words
Fosamprenavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by amprenavir (boosted by ritonavir if present) reduces prednisolone clearance.
What to do
Monitor for Cushingoid effects, hyperglycemia and adrenal suppression with long-term use, and use the lowest effective prednisone dose. Consider an alternative less CYP3A4-dependent steroid for prolonged therapy with ritonavir-boosted regimens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Fosamprenavir with Prednisone?
MediHelp rates the interaction as moderate. Fosamprenavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amprenavir, the active metabolite of fosamprenavir, inhibits CYP3A4 and may modestly increase prednisolone exposure, raising the risk of corticosteroid adverse effects with prolonged use. Corticosteroids may in turn lower amprenavir levels slightly.
How serious is the interaction between Fosamprenavir and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid effects, hyperglycemia and adrenal suppression with long-term use, and use the lowest effective prednisone dose. Consider an alternative less CYP3A4-dependent steroid for prolonged therapy with ritonavir-boosted regimens.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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