Drug interactions
Fosamprenavir + Propafenone
Severity: Major
Fosamprenavir and Propafenone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, as amprenavir, inhibits CYP3A4 and may increase propafenone exposure. This raises the risk of proarrhythmia and conduction abnormalities, and boosted protease inhibitors may amplify it.
What this interaction means in plain words
Fosamprenavir and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated metabolism of propafenone.
What to do
Monitor ECG and consider lowering the propafenone dose. Use an alternative antiarrhythmic if the combination is poorly tolerated, especially when ritonavir is co-prescribed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Propafenone?
MediHelp rates the interaction as major. Fosamprenavir and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, as amprenavir, inhibits CYP3A4 and may increase propafenone exposure. This raises the risk of proarrhythmia and conduction abnormalities, and boosted protease inhibitors may amplify it.
How serious is the interaction between Fosamprenavir and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and consider lowering the propafenone dose. Use an alternative antiarrhythmic if the combination is poorly tolerated, especially when ritonavir is co-prescribed.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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