Drug interactions
Fosamprenavir + Regorafenib
Severity: Major
Fosamprenavir and Regorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (amprenavir), especially ritonavir-boosted, inhibits CYP3A4 and can increase regorafenib exposure with unpredictable effects on active metabolites.
What this interaction means in plain words
Fosamprenavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition reduces regorafenib metabolism.
What to do
Avoid coadministration where possible. If required, monitor liver tests and for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Fosamprenavir with Regorafenib?
MediHelp rates the interaction as major. Fosamprenavir and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir (amprenavir), especially ritonavir-boosted, inhibits CYP3A4 and can increase regorafenib exposure with unpredictable effects on active metabolites.
How serious is the interaction between Fosamprenavir and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If required, monitor liver tests and for toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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